研究成果 | 科研项目： 1. 国家自然科学基金委员会，重点项目，82530079, 酮体抑制疟原虫红内期发育繁殖的分子机理,202601-2030.12，233万元，在研。 2. 国家自然科学基金委员会，面上项目，32573395, 弓形虫蛋白质翻译后修饰对虫体发育和转化的调控机理，2026.01-202029.12，51万元，在研。 3. 农业部，国家重点研发计划，2022YFD1800200,动物重要寄生虫的生长发育与寄生机制，2022.11-2025.12,2000万元，结题。 4. 国家自然科学基金委员会，重点项目，82030060,恶性疟原虫红内期发育繁殖过程中蛋白质修饰及作用机理, 2021.01-2025.12,297万元，结题。 5. 国家自然科学基金委员会，面上项目，32072880，锥虫蛋白质乳酸化修饰及生物学意义分析，2021.01-2024.12，59万元，结题。 5. 科技部，国家重点研发计划，2017YFD0500400，畜禽重要胞内寄生原虫的寄生与免疫机制研究，2017.7-2020.12,1850万元，结题。 6. 科技部，常規性科技援助項目，KY20190l014，中蒙一带一路重点实验室，2019.12-2022.12，277万元，结题。 7. 国家自然科学基金委员会，重点国际合作项目，81420108023，恶性疟原虫与侵入红细胞相关的新型蛋白质及功能分析，2025.01-2019.12,300万元，结题。 8. 国家自然科学基金委员会，重点项目，81130033，疟原虫 TatD-like DNase 的功能分析及与虫体致病的相关性分析，2012.01-2016.12,240万元，结题。 9. 国家自然科学基金委员会，国家杰出青年基金项目，30625029，附红细胞体病原生物学研究，2007.01-2010.12,200万元，结题。 10. 国家自然科学基金委员会，国家杰出青年基金（海外杰出青年基金）项目，兽医寄生虫病学，2004.01-2006.12,40万元，结题。 研究论文： 1. Chen, Q†., Fernandez, V†., Sundstrom, A., Schlichtherle, M., Datta, S., Hagblom, P., and Wahlgren, M.* Developmental selection of var gene expression in Plasmodium falciparum. Nature. 1998.07. 2.Brolin, K.†, Ribacke, U.†, Nilsson, S., Ankarklev, J., Moll, K., Wahlgren, M., and Chen, Q.* Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites. Genome Biology. 2009.10. 3.Chang, Z., Jiang, N., Zhang, Y., Lu, H., Yin, J., Wahlgren, M., Cheng, X., Cao, Y., and Chen, Q.* The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate. Nature Communications. 2016.05. 4.Li,Q.†,Lv,K.†,Jiang,N.†,Liu,T.,Hou.N.,...Cao,Y., and Chen, Q.* SOD3 suppresses early cellular immune responses to parasite infection. Nature Communications. 2024.06. 5.Yin, D., Jiang, N., Cheng, C., Sang, X., Feng, Y., Chen, R. and Chen, Q.* Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii. Genomics Proteomics Bioinformatics .2023.10. 6.Wei Z.†, Jiang N.†, Zhang Y.†, Li Q.†, Su Z.,... Chen R., and Chen Q.* β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice. Nature Metabolism. 2025.05. 7.Li, Q.†, Yuan, Q.†,Jiang, N.†, Zhang, Y., ...Feng, Y., and Chen, Q.* Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation. Signal Transduction and Targeted Therapy. 2022.07. 8.Zhang, T.†, Zhang, Y.†, Jiang, N.†, Zhao, X., ...Chen, R. and Chen, Q.* Dihydroartemisinin regulates the immune system by promotion of CD8 + T lymphocytes and suppression of B cell responses. SCIENCE CHINA-Life Sciences. 2020.01. 9.Su, Z.†, Li, Q.†, Zhang, Y.†, Liu, T.,...Jiang,N. and Chen, Q.* Ly6G+ Neutrophilsand Interleukin-17 Are Essential inProtection against Rodent MalariaCaused by Plasmodium bergheiANKA. Research. 2024.12. 10.Li, Q., Liu, T., Lv, K.,Liao, F.,Wang, J.,Tu, Y., Chen, Q.* Malaria: past, present, and future. Signal Transduction and Targeted Therapy. 2025.06. 11.Liu,Y.†,Jiang,N.†,Zuo,S.,Feng,Y.,... Sang, Z., and Chen,Q.* Graphene quantum dots disrupt the mitochondrial potential of Trypanosoma brucei by interacting with the p18 subunit of ATP synthase F1 after endocytosis via the VSG recycling pathway. Journal of Colloid And Interface Science. 2025.02 12.Zheng,K.†, Li,Q.†, Jiang,N., Feng,Y., Chen,R., Sang,X., Chen,Q*. Plasmodium falciparum selectively degrades α-spectrin of infected erythrocytes after invasion. mBio. 2024.04 13.Li, Q.†, Jiang, N.†, Zhang, Y., Liu, Y., ...Feng, Y., and Chen, Q.* Dihydroartemisinin imposes positive and negative regulation on Treg and plasma cells via direct interaction and activation of c-Fos. Communications Biology. 2023.01. 14. Zhang,Y.†, Li,Q.†, Jiang,N.†, Su,Z., ...Feng,Y., and Chen, Q.* Dihydroartemisinin beneficially regulates splenic immune cell heterogeneity through the SOD3-JNK-AP-1 axis. SCIENCE CHINA Life Sciences. 2022.08. 15.Zhang,N.,Jiang,N.,Yu, L.,Guan, T.,Sang, X.,Feng, Y.,Chen, R.,Chen, Q.* Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei. Frontiers in cell and developmental biology. 2021.10. 16.Wang, X.†, Xie, Y.†, Jiang, N., ... Chen R., and Chen, Q.* Enhanced Antimalarial Efficacy Obtained by Targeted Delivery of Artemisinin in Heparin-Coated Magnetic Hollow Mesoporous Nanoparticles. ACS Appl. Materials and Interfaces. 2021.01. 17.Wang, J., Jiang, N., Sang, X., Yang, Na., Feng,Y., Chen, R., Wang, Xin., and Chen, Q.* Protein modification characteristics of the malaria parasite Plasmodium falciparum and the infected erythrocytes. Molecular & Cellular Proteomics. 2021.01. 18.Xing, M., Yang, Na., Jiang, N., Wang, D., Sang, X., Feng, Y., Chen, Ran., Wang, X., and Chen, Q.* A Sialic Acid-Binding Protein SABP1 of Toxoplasma gondii. Mediates Host Cell Attachment and Invasion. The Journal of Infectious Diseases. 2020.07. 19.Zhang, N., Jiang, N., Zhang, K., ..Lun, Z., and Chen, Q.* Landscapes of Protein Posttranslational Modifications of African Trypanosoma Parasites, iSCIENCE. 2020.05. 20.Yin, D., Zhang, Y., Wang, D.,...Jiang, N., and Chen, Q.* Global lysine crotonylation and 2-hydroxy- isobutyrylation inphenotypically different Toxoplasma gondii parasites. Molecular & Cellular Proteomics. 2019.09.
授权专利 1. 陈启军；姜宁；张义伟；李其龙；陈冉；冯颖；SOD3在调控双氢青蒿素诱导的脾脏增大及免疫细胞异质性药物筛选或疫苗评价中的应用，2024-04-02，中国，ZL202210048341.0. 2. 陈启军；桑晓宇；姜宁；张义伟；冯颖；陈冉；李响；基于生物膜干涉技术检测病原生物凝集素与唾液酸乳糖亲和力方法的建立，2022-11-17，中国，ZL202211461812.7. 3. 陈启军；杨娜；姜宁；丁莹莹；桑晓宇；冯颖；陈冉；王新一；牛细粒棘球蚴病时间分辨荧光免疫层析检测试纸条及其制备方法，2023-02-07，中国，ZL202010318134.3. 4. 陈启军；姜宁；刘铮；一种马梨形虫病双重TaqMAN探针荧光定量PCR检测方法，2023-08-08，中国，ZL201910615880.6. 5. 陈启军；姜宏波；包杰；李晓东；申洪彬；用于检测二尖梅奇酵母的引物对及其应用，2023-05-05，中国，ZL202011134597.0. 6. 陈启军；张东超；姜宁；弓形虫SAG2基因和ROP9基因重组腺病毒构建的方法及重组腺病毒和应用，2022-05-10，中国，ZL201811323001.4. 7. 陈启军；姜宁；贾博寅；可检测感染弓形虫的标识性 mmu-miR-712-3p，2016-04-13，中国，ZL201410072189.5. 8. 陈启军；贾博寅；姜宁；可检测感染弓形虫的标识性mmu-miR-217-5p，2016-04-13，中国，ZL201410072202.7. 9. 陈启军；李烨馨；姜宁；杨娜；桑晓宇；冯颖；一种适用于弓形虫的ELISA的方法，2019-11-05，中国，ZL201711381495.7. 10. 陈启军；姜宁；杜承；尹继刚；陆慧君；一种可抑制恶性疟原虫侵入的抗Pf332-DBL区单克隆抗体，2012-09-12，中国，ZL201010174866.6.
著作教材 1.陈启军；高维凡；吴长德；姜宁；什么是动物医学？大连理工大学出版社，80千字，2022，专著. 2.索勋；潘保良；汪明；陈启军（编委）；兽医寄生虫学；中国农业出版社，1015千字，教材. |
